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Proposed mechanisms include: DSIP-induced upregulation of downstream receptor systems that outlast the peptide itself

The rubber stopper hasn't been punctured, the vacuum seal is intact, and the internal environment is protected from the outside world

Natural antioxidants can protect mitochondrial integrity and function, thereby reducing the production of ROS

Data availability Data will be shared with bona fide researchers who submit a research proposal approved by the independent review board

Orthoester linkages There are only a limited number of studies on poly(orthoester)-based pH-sensitive polymeric nanoparticles for targeted drug delivery because only a couple of synthetic strategies are available to prepare these types of polymers